交换名片

Fludarabine | 氟达拉滨

MCE 国际站：Fludarabine

中文名：氟达拉滨

CAS：21679-14-1

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Fludarabine (NSC 118218) 是一种 DNA 合成 抑制剂和氟化嘌呤类似物，在淋巴增生性恶性肿瘤中具有抗肿瘤活性。氟达拉滨抑制正常静息或活化淋巴细胞中细胞因子诱导的 STAT1 激活和 STAT1 依赖基因转录^[1]^[2]^[3]^[4]。体外氟达拉滨（5 μM；48 小时）诱导 p27kip1 表达降低^[4]。 体内：氟达拉滨（0.8?mg/kg；ip；两个周期，每 2 周 5 天）与环磷酰胺（400?mg/kg；ip；2周）降低 GVHD 的发生率^[5]。

体外：Fludarabine（5 μM；48 小时）诱导 p27kip1 表达降低^[4]。

体内：氟达拉滨（0.8 mg/kg；ip；两个周期，每 2 周 5 天）与环磷酰胺（400 mg/kg；ip；2 周）联合使用可降低 GVHD 的发生率^[5]。

研究领域：Cell Cycle/DNA Damage | Stem Cell/Wnt | JAK/STAT Signaling | Apoptosis

作用靶点：Nucleoside Antimetabolite/Analog | DNA/RNA Synthesis | STAT | Apoptosis

参考文献：
[1]. Tournilhac O, et al. Impact of frontline fludarabine ａnd cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood. 2004 Jan 1;103(1):363-5. Epub 2003 Sep 11.
[2]. Liang YB, et al. Downregulated SOCS1 expression activates the JAK1/STAT1 pathway ａnd promotes polarization of macrophages into M1 type. Mol Med Rep. 2017 Nov;16(5):6405-6411.
[3]. Sanhes L, et al. Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases. Leukemia. 2003 Jun;17(6):1104-11.
[4]. Weiss L, et al. Fludarabine in combination with cyclophosphamide decreases incidence of GVHD ａnd maintainseffective graft-versus-leukemia effect after allogeneic stem cell transplantation in murinelymphocytic leukemia. Bone Marrow Transplant. 2003 Jan;31(1):11-5.
[5]. Frank DA,et al. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med. 1999 Apr;5(4):444-7.
[6]. Frank DA, et al. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med. 1999;5(4):444-447.