产品编号Rs-20099R 英文名称ARL8B 中文名称ADP核糖基化样因子8B抗体 别 名ADP ribosylation factor like 10C; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8B; ARL10C; ARL8B; ARL8B_HUMAN; FLJ10702; Gie1; Novel small G protein indispensable for equal chromosome segregation 1. 说 明 书0.1ml 0.2ml 研究领域细胞生物 细胞周期蛋白 细胞分化 表观遗传学 抗体来源Rabbit 克隆类型Polyclonal 交叉反应Human, Mouse, Rat, Cow, Rabbit, 产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量22kDa 细胞定位细胞浆 细胞膜 性 状Lyophilized or Liquid 浓 度1mg/1ml 免 疫 原KLH conjugated synthetic peptide derived from human ARL8B 亚 型IgG 纯化方法affinity purified by Protein A 储 存 液0.01M TBS（pH7.4） with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol. 保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMedPubMed 产品介绍background: ADP-ribosylation factors （ARFs） are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of Cholera Toxin. ARF’s are important in eukaryotic vesicular trafficking pathways ａnd they play an essential role in the activation of phospholipase D （PC-PLD）. ARL8B （ADP-ribosylation factor-like protein 8B）, also known as ARL10C or GIE1, is a 186 amino acid protein that localizes to the late endosome membrane ａnd belongs to the ARL family of ARF-like GTPase proteins. Expressed ubiquitously, ARL8A interacts with Tubulin ａnd is thought to play a role in lysosome motility, as well as in chromosomal segregation. The gene encoding ARL8B maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor （CKR） gene cluster ａnd a variety of human cancer-related gene loci.
Function: May play a role in lysosome motility （PubMed:16537643）. May play a role in chromosome segregation （PubMed:15331635）.
Subunit: Interacts with tubulin.
Subcellular Location: Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle.
Tissue Specificity: Ubiquitously expressed.
Similarity: Belongs to the small GTPase superfamily. Arf family.
Gene ID: 55207
Database links: Entrez Gene: 55207 Human SwissProt: Q9NVJ2 Human Unigene: 250009 Human
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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