提供者：上海笃玛生物科技有限公司 发布时间：2024/9/12 13:26:10 阅读次数：2704次 进入该公司店铺
| Product Name | PPM1A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
WB~~1:100~500 IHC~~1:50~100: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Gene Synonyms | |
|---|---|
| Alternative Names | Hide |
| Molecular Weight(MW) | 42448 Da |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 ａnd SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs ａnd termination of the TGF-beta-mediated signaling |
| Tissue Specificity | This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64~94 amino acids from the center region of human PPM1A. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 5494 |
|---|
Western blot analysis of hPPM1A-C72 (RB06012) in HL-60 cell line lysates (35ug/lane).PPM1A (arrow) was detected using the purified Pab.
Western blot analysis of PPM1A (arrow) using rabbit polyclonal hPPM1A-C72 . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PPM1A gene (Lane 2) (Origene Technologies).
Formalin-fixed ａnd paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
| Application Notes | WB~~1:100~500 IHC~~1:50~100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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