Lactoferrin

MCE 国际站：Lactoferrin

CAS：936541-36-5

品牌：MedChemExpress (MCE)

存储条件：Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性：Lactoferrin (乳铁蛋白) 是中性粒细胞释放的物质。Lactoferrin 是一种具有口服活性的多功能铁结合糖蛋白。Lactoferrin 可防止细胞粘附、细胞集落的生长和扩散。Lactoferrin 还具有抗病毒活性，抑制微生物和病毒粘附和进入宿主细胞。此外，Lactoferrin 具有抗炎、免疫调节和抗癌活性。

体外：Lactoferrin (0-1 000 μg/mL，7 天) 以剂量依赖性方式抑制上皮细胞 (HaCaT) 生长
[1]。 Lactoferrin (500 μg/mL，12 天) 抑制 HaCaT 细胞集落的扩散和生长
[1]。 Lactoferrin (人或牛乳铁蛋白，1.41 μM 和 0.12 μM）可抑制 Vero 细胞中的 HSV-1 感染达 50%
[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Lactoferrin (重组人乳铁蛋白) (1,000 mg/kg，口服灌胃，每天两次，持续 8 天) 可抑制 80% 的 T 细胞免疫功能低下的 nu/nu 小鼠鳞状细胞癌 (O12) 肿瘤的生长
[5] 。 Lactoferrin (牛乳铁蛋白) (100 和 200 mg/kg，口服灌胃，连续 30 天) 对败血症诱发的急性肺损伤大鼠模型显示出保护作用
[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)
[5] Dosage: 1,000 mg/kg Administration: oral gavage, twice daily for 8 days Result: Inhibited the tumor growth by 80%. Animal Model: Sepsis-induced acute lung injury rat model
[6] Dosage: 100 ａnd 200 mg/kg Administration: oral gavage,for 30 consecutive days Result: Reduced the wet/dry ratio of lung tissue by 30.7% ａnd 61.3%, ａnd lipid peroxidation by 22.3% ａnd 67%, at concentrations of 100 ａnd 200mg/kg. Reduced Inflammatory markers, neutrophils, lymphocytes ａnd total cell count. Reduced MPO activity. Clinical Trial

热销产品：Lithium dodecyl sulfate | Amantadine | 5,6-Dihydroxyindole | Lactose | Parsaclisib | Lactobionic acid | RBC8 | Pyridostigmine (bromide) | Oxyresveratrol | Cytidine

研究领域：Anti-infection

作用靶点：HSV

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸

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参考文献：
[1]. Pllnen MT, et al. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res. 1998 Jan;33(1):8-16.
[2]. Berlutti F, et al. Antiviral properties of lactoferrin－－a natural immunity molecule. Molecules. 2011 Aug 16;16(8):6992-7018.
[3]. Cutone A, et al. Lactoferrin＇s Anti-Cancer Properties: Safety, Selectivity, ａnd Wide Range of Action. Biomolecules. 2020 Mar 15;10(3):456.
[4]. Marchetti M, et al. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 1996 Mar;29(2-3):221-31.
[5]. Varadhachary A, et al. Oral lactoferrin inhibits growth of established tumors ａnd potentiates conventional chemotherapy. Int J Cancer. 2004 Sep 1;111(3):398-403.
[6]. Han N, et al. Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury. AMB Express. 2019 Oct 31;9(1):177.