Anagrelide (hydrochloride) | 盐酸阿那格雷

MCE 国际站：Anagrelide (hydrochloride)

中文名：盐酸阿那格雷

CAS：58579-51-4

品牌：MedChemExpress (MCE)

存储条件：4°C, sealed storage, away from moisture

生物活性：Anagrelide hydrochloride (BL4162A) 是一种用于治疗原发性血小板增多症的药物。目标：PDE Anagrelide hydrochloride 是一种口服咪唑并喹唑啉药物，已被证明可以降低血小板计数升高和各种骨髓增生性疾病 (MPD) 血小板增多症患者的血栓形成风险。它目前被 FDA 批准用于治疗原发性血小板增多症 (ET) 和与真性红细胞增多症 (PV) 相关的血小板增多症。已知阿那格雷抑制血小板环磷酸腺苷 (cAMP) 磷酸二酯酶的浓度超过用于治疗 ET 的剂量。阿那格雷在肝脏中广泛代谢，其代谢物主要通过尿液排泄
[1]。阿那格雷是一种公认的降血小板药物。研究还调查了阿那格雷对血小板的影响，表明血小板功能与 ET 中的血小板计数一样重要
[2]。

体外：Anagrelide hydrochloride (BL4162A) 有效抑制骨髓巨核细胞的发育 (IC50=26nM)
[1]。 Anagrelide (0.05、0.3、1 M；12 天) hydrochloride 仅抑制巨核细胞生长，不抑制非巨核细胞生长
[2]。 Anagrelide (0.1-10000 nM) hydrochloride 在 GIST882 细胞系中诱导细胞毒性作用
[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Anagrelide hydrochloride (BL4162A; 5 mg/kg/bid；持续 10 天) 抑制或减少 GIST2B、GIST9、GIST882 模型中的肿瘤生长
[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model
[3] Dosage: 5 mg/kg Administration: Twice daily; for 10 days Result: Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models. Clinical Trial

热销产品：Bay 60-7550 | AZD0156 | Bestatin | 7,8-Dihydroxyflavone | Iberdomide | Mitoxantrone | Neratinib | Octreotide (acetate) | PhiKan 083 | (Z)-Ligustilide

研究领域：Metabolic Enzyme/Protease | Apoptosis

作用靶点：Phosphodiesterase (PDE) | Apoptosis

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

参考文献：
[1]. Pescatore, S.L. ａnd C. Lindley, Anagrelide: a novel agent for the treatment of myeloproliferative disorders. Expert Opin Pharmacother, 2000. 1(3): p. 537-46.
[2]. Petrides, P.E., Anagrelide: what was new in 2004 ａnd 2005? Semin Thromb Hemost, 2006. 32(4 Pt 2): p. 399-408.