前列腺素 E2;地诺前列酮;前列腺素E2

CAS No. : 363-24-6

MCE 国际站：Prostaglandin E2

产品活性：Prostaglandin E2 (PGE2) 是一种激素样物质，参与广泛的身体功能，如平滑肌的收缩和松弛，血管的扩张和收缩，血压的控制和炎症的调节。

研究领域：GPCR/G Protein | Metabolic Enzyme/Protease

作用靶点：Prostaglandin Receptor | Endogenous Metabolite

结构分类：酮、醛、酸

In Vitro: PGE2 shows inhibition of IL 2 production in the mixture of irradiated ａnd nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production ａnd PHA proliferation.

In Vivo: PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min ａnd is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction.

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