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磷酰胺二钠

CAS No. : 164204-38-0

MCE 国际站：Phosphoramidon Disodium

产品活性：Phosphoramidon Disodium，一种微生物代谢物 (microbial metabolite)，是一种特异性金属蛋白酶嗜热菌蛋白酶 (metalloprotease thermolysin) 抑制剂，其IC₅₀ 为0.4 μg/mL。Phosphoramidon Disodium 也抑制内皮素转换酶 (ECE)、中性肽酶 (NEP) 和血管紧张素转换酶(ACE)，IC₅₀ 分别为 3.5、0.034 和 78 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：MMP | Angiotensin-converting Enzyme (ACE) | Neprilysin | Endogenous Metabolite

结构分类：生物碱 | 吲哚类生物碱

In Vitro: Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes.

In Vivo: Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats.
Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats.

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