交换名片

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

角黄素;斑蝥黄质;斑蝥黄;裸藻酮

CAS No. : 514-78-3

MCE 国际站：Canthaxanthin

产品活性：Canthaxanthin是具有多种生物活性的红橙色类胡萝卜素，如抗氧化，抗肿瘤活性。

研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species | Endogenous Metabolite

结构分类：萜类 | 其他萜类

In Vitro: Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging ａnd antioxidant properties (e.g., the induction of catalase ａnd superoxide dismutase), canthaxanthin shows immunomodulatory activity (e.g. enhancing the proliferation ａnd function of immune competent cells) ａnd plays important role in gap junction communication (e.g. induction of the transmembrane protein connexin). At concentrations of 0.1 to 1 x 1000 μM, canthaxanthin significantly reduces the overall number of tumor cells. The greatest inhibition is observed at a canthaxanthin concentration of 1000 after 72 h ａnd 96 h of incubation.

In Vivo: Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver ａnd reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower ａnd catalase (59%) ａnd manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls. Canthaxanthin inhibit the growth of mammary tumors in mice ａnd the anti-tumor activity is also influenced by the supplemental dose. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity.