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Puromycin dihydrochloride

CAS No. : 58-58-2

MCE 国际站：Puromycin dihydrochloride

产品活性：Puromycin dihydrochloride (CL13900 dihydrochloride) 是一种氨基核苷类抗生素，抑制蛋白合成 (protein synthesis)。

研究领域：Anti-infection

作用靶点：Bacterial | Antibiotic | Parasite

结构分类：抗生素 | 其他类

In Vitro: Puromycin blocks protein synthesis after aminoacyl-sRNA formation, ａnd at the same time it leads to the accumulation of small peptides. Both of these effects appear to be due to the splitting of ribosome-bound peptidyl-sRNA,4 which results in release of incomplete peptide chains..
Puromycin, an analog of the 3＇ end of aminoacyl-tRNA, causes premature termination of translation by being linked non-specifically to growing polypeptide chains. Puromycin has two modes of inhibitory action. The first is by acting as an acceptor substrate which attacks peptidyl-tRNA in the P site to form a nascent peptide. The second is by competing with aminoacyl-tRNA for binding to the A＇ site.
When used in minimal amounts, puromycin incorporation in neosynthesized proteins reflects directly the rate of mRNA translation in vitro. Puromycin immunodetection is an advantageous alternative to radioactive amino acid labeling. It allows the direct evaluation of translation activity in single cells by immunofluorescence microscopy ａnd in heterogenous populations of cells by fluorescenceactivated cell sorting.

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