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L-(+)-Abrine

MCE 国际站：L-(+)-Abrine

品牌：MedChemExpress (MCE)

货号：HY-N1436

CAS 号：526-31-8

生物活性： L-(+)-相思碱，一种存在于相思子种子中的致命白蛋白，是一种急性毒性生物碱，也是相思碱的化学标记物。

体外研究(In Vitro)：L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

体内研究(In Vivo)：Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD50 i.p. abrin in mice, assuming a concentration ratio of 1:4 of abrin to L-(+)-Abrine and an LD50 for abrin of 20 µg/kg. The mid and high L-(+)-Abrine (250 and 400 µg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：218.25

Formula：C12H14N2O2

性状：固体

颜色：Off-white to light yellow

中文名称：L-(+)-相思子碱；L-(+)-相思豆碱；L-(+)-红豆碱

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：粉末 -20°C 3年

Animal Administration [2]：Rats[2] Twenty male Wistar rats, approximately 6⁻⁷ weeks of age and weighing approximately 175-200 g upon receipt, are used. A total of 12 rats are dosed intramuscularly with L-(+)-Abrine at 0.63, 3.13, and 5 times the expected Abrin LD50 of 20 µg/kg. Although no toxin is used here, the concentration of the biomarker is increased by a factor of 4 to estimate an equivalent level of toxin, assuming that Labrine is present in rosary peas at a concentration four times greater that the toxin abrin. A total of 12 rats are dosed intramuscularly with L-(+)-Abrine: four at approximately 50 µg/kg body weight (bw), four at 250 µg/kg bw, and four at 400 µg/kg bw. Four control rats are dosed with water, which is the vehicle for all dosing experiments. Another four rats are dosed intraperitoneally with 20,000 µg/kg L-tryptophan to verify that endogenous L-tryptophan is not metabolized to L-(+)-Abrine[2]. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、SDS、COA、HNMR、LCMS、产品使用指南

产品活性：L-(+)-Abrine 是在 Abrus precatorius 种子中发现的一种致命白蛋白，是一种急性毒性生物碱，可用作化学标记物。

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参考文献：
[1]. Cho H, et al. A portable and chromogenic enzyme-based sensor for detection of abrin poisoning. Biosens Bioelectron. 2014 Apr 15;54:667⁻⁷3.
[2]. Johnson RC, et al. Quantification of L-abrine in human and rat urine: a biomarker for the toxin abrin. J Anal Toxicol. 2009 Mar;33(2):77-84.