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Senecionine

MCE 国际站：Senecionine

品牌：MedChemExpress (MCE)

货号：HY-N2560

CAS 号：130-01-8

生物活性：千里光碱（千里光烷-11,16-二酮，12-羟基-）是一种吡咯里西啶生物碱，可从千里光中分离得到。千里光碱可降低谷胱甘肽S-转移酶、氨基比林脱甲基酶和芳烃羟化酶（AHH）的活性[1][2][3]。

体外研究(In Vitro)：Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world´s flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

体内研究(In Vivo)：Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides[1]. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH[2]. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth[3]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：335.39

Formula：C18H25NO5

性状：固体

颜色：White to off-white

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式： 4°C，避光保存 *溶剂保存：-80°C，6个月；-20°C，1个月（避光保存）

Animal Administration [1]：Rats[1] Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4)[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、SDS、COA、HNMR、RP-HPLC、MS、产品使用指南

产品活性：Senecionine (Senecionan-11,16-dione, 12-hydroxy-) 是一种可以从 Senecio vulgaris 中分离出来的吡咯里西啶生物碱。 Senecionine 会降低谷胱甘肽-S-转移酶、氨基比林脱甲基酶和 AHH 的活性。

相关产品：PEG1000000 | PEG200000 | PEG5000000 | PEG8000000 | SBE-β-CD | PEG300 | PEG400 | PEG100000 | PEG2000 | PEG3350 | PEG1500 | PEG600

热门产品线：多肽 | 寡核苷酸 | 天然产物 | 生化试剂 | 荧光染料

Trending products：Peptides | Oligonucleotides | Natural Products | Biochemical Assay Reagents | Fluorescent Dyes

参考文献：
[1]. Wang C, et al. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem. 2011 Jul;401(1):275-87.
[2]. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8.
[3]. Tu ZB, et al. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J Pharm Sci. 1988 May;77(5):461-3.