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FITC标记的锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
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价格：￥电议
更新日期：2026/8/7 18:14:45
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相关标签：FITC标记的锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
详细内容
| 英文名称 | Anti-ASB3/FITC |
| 中文名称 | FITC标记的锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体 |
| 别 名 | Ankyrin repeat ａnd SOCS box containing 3; Ankyrin repeat ａnd SOCS box containing protein 3; Ankyrin repeat ａnd SOCS box protein 3; ASB-3; ASB3; ASB3_HUMAN; Weakly similar to ankyrin brain variant 2. |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASB3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins ａnd their binding partners with the elongin B ａnd C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat ａnd SOCS box-containing (ASB) protein family are identified ａnd termed as ASB-1, ASB-2, ASB-3 ａnd ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid (RA)-induced gene in acute promyelocytic leukemia (APL) cells ａnd its expression induces growth-inhibition ａnd chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter. Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination ａnd subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Subunit: Interacts with TCEB2 ａnd TNFRSF1B. Similarity: Contains 11 ANK repeats. Contains 1 SOCS box domain. Database links: UniProtKB/Swiss-Prot: Q9Y575.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
FITC标记的锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
