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FITC标记的花生四烯酸15脂氧合酶1抗体
点击次数：149
价格：￥电议
更新日期：2026/8/7 18:14:45
生 产 地：中国大陆
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相关标签：FITC标记的花生四烯酸15脂氧合酶1抗体
详细内容
| 英文名称 | Anti-15 Lipoxygenase 1/FITC |
| 中文名称 | FITC标记的花生四烯酸15脂氧合酶1抗体 |
| 别 名 | 15 LOX; 15 LOX 1; 15-LOX; 15LOX 1; ALOX15; Arachidonate 15 lipoxygenase; Arachidonate 15-lipoxygenase; Arachidonate omega 6 lipoxygenase; Arachidonate omega-6 lipoxygenase; LOX15_HUMAN; 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE. |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 73kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes ａnd synthesis of signaling molecules, as well as inducing structural ａnd metabolic changes in the cell. The Lox enzymes in mammals include 12-LO ａnd 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth ａnd proliferation, as well as survival ａnd apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling ａnd the pathogenesis of atherosclerosis, inflammation, ａnd carcinogenesis. It is highly regulated ａnd expressed in a tissue- ａnd cell-type-specific fashion. IL-4 ａnd IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression ａnd activation. Function: Oxygenase ａnd 14,15-leukotriene A4 synthase activity. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid. Subunit: Homotetramer. Can also form heterotetramers with RYR2. Interacts with CALM; CALM with bound calcium inhibits the RYR1 channel activity. Interacts with S100A1. Interacts with FKBP1A; this stabilizes the closed conformation of the channel. Interacts with CACNA1S; interaction with CACNA1S is important for activation of the RYR1 channel. Interacts with CACNB1. Interacts with TRDN ａnd ASPH; these interactions stimulate RYR1 channel activity (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A ａnd protein phosphatase 1 (PP1). Repeated very high-level exercise decreases interaction with PDE4D ａnd protein phosphatase 1 (PP1). Subcellular Location: Cytoplasm. Tissue Specificity: Skeletal muscle ａnd brain (cerebellum ａnd hippocampus). Post-translational modifications: Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2843 may increase channel activity. Repeated very high-level exercise increases phosphorylation at Ser-2843. Activated by reversible S-nitrosylation. Repeated very high-level exercise increases S-nitrosylation. |
FITC标记的花生四烯酸15脂氧合酶1抗体
