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FITC标记的甘油酯激酶线粒体抗体
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价格：￥电议
更新日期：2026/8/7 18:14:45
生 产 地：中国大陆
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相关标签：FITC标记的甘油酯激酶线粒体抗体
详细内容
| 英文名称 | Anti-Acylglycerol Kinase/FITC |
| 中文名称 | FITC标记的甘油酯激酶线粒体抗体 |
| 别 名 | mitochondrial; Acylglycerol kinase; Acylglycerol kinase mitochondrial; agk; AGK_HUMAN; hAGK; HsMuLK; MuLK; Multi substrate lipid kinase; Multi-substrate lipid kinase; Multiple substrate lipid kinase. |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 激酶和磷酸酶 肿瘤细胞生物标志物 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 细胞定位 | 细胞膜 线粒体 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Acylglycerol Kinase |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a mitochondrial membrane protein involved in lipid ａnd glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic ａnd lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. Function: Lipid kinase that can phosphorylate both monoacylglycerol ａnd diacylglycerol to form lysophosphatidic acid (LPA) ａnd phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation ａnd secretion of LPA, resulting in transactivation of EGFR ａnd activation of the downstream MAPK signaling pathway, leading to increased cell growth. Subcellular Location: Mitochondrion membrane. Tissue Specificity: Highly expressed in muscle, heart, kidney ａnd brain. DISEASE: Defects in AGK are the cause of mitochondrial DNA depletion syndrome type 10 (MTDPS10) [MIM:212350]. An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, ａnd lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. Defects in AGK are the cause of cataract, congenital, autosomal recessive type 5 (CATC5) [MIM:614691]. CATC5 consists of an opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, ａnd may be static or progressive. In general, the more posteriorly located ａnd dense an opacity, the greater the impact on visual function. |
FITC标记的甘油酯激酶线粒体抗体
