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FITC标记的酪氨酸蛋白激酶受体A8抗体
点击次数：168
价格：￥电议
更新日期：2026/8/7 18:14:45
生 产 地：中国大陆
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相关标签：FITC标记的酪氨酸蛋白激酶受体A8抗体
详细内容
| 英文名称 | Anti-EphA8/FITC |
| 中文名称 | FITC标记的酪氨酸蛋白激酶受体A8抗体 |
| 别 名 | 2.7.1.112; EEK; EK3; EPH ａnd ELK related kinase; EPH like kinase 3; Eph receptor A8; EPH- ａnd ELK-related kinase; EPH-like kinase 3; EphA8; EPHA8_HUMAN; Ephrin Type A Receptor 8 Precursor; Ephrin type-A receptor 8; HEK3; KIAA1459; Tyrosine-protein kinase receptor EEK; Tyrosylprotein Kinase. |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 神经生物学 信号转导 激酶和磷酸酶 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 108kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human EphA8/Eph receptor A8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH ａnd EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain ａnd an extracellular region containing a Cys-rich domain ａnd 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences ａnd their affinities for binding ephrin-A ａnd ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 ａnd A5 ａnd plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008] Function: Receptor for members of the ephrin-A family. Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer ａnd a receptor dimer. Oligomerization is probably required to induce biological responses. May also form heterodimers with other ephrin receptors (By similarity). Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A ａnd ANKS1B; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination. Subcellular Location: Membrane. Post-translational modifications: Phosphorylation on Tyr-616 is critical for association with FYN. Phosphorylation on Tyr-839 modulates tyrosine kinase activity. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
FITC标记的酪氨酸蛋白激酶受体A8抗体
