提供者:上海雅吉生物科技有限公司 发布时间:2026/10/22 8:41:33 阅读次数:7次 进入该公司店铺
文章标题:Machine learning combined with WGCNA reveals potential calcium uptake-associated biomarkers in Parkinson’s disease
作者列表:Wangzhouyang Lou, Juqin Wu
影响因子:1.8
期刊:ANNALS OF HUMAN BIOLOGY
发表时间:2026-5-13
DOI:10.1080/03014460.2026.2661601
文献主题:Abstract
Background
Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterised by progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Although previous studies have suggested a correlation between calcium signal disruption and the development of PD, the role of genes associated with store-operated calcium entry (SOCE) in PD remains unclear.
Aim
To combine machine learning methods with Weighted Gene Co-expression Network Analysis (WGCNA) to systematically screen and identify SOCE-associated candidate genes and evaluate their potential for assisting in discrimination.
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