产品类型

宠物抗体、农牧业/家禽抗体

英文名称

SPTBN2 Rabbit pAb

中文名称

非红细胞血影脑蛋白β2/spectrin β III抗体

英文别名

beta III spectrin; beta-III spectrin; SCA 5; SCA5; Spectrin beta chain brain 2; Spectrin beta non erythrocytic 2; Spectrin non erythroid beta chain 2; Spinocerebellar ataxia 5; SPTBN 2; Spectrin beta chain, non-erythrocytic 2; beta-III spectrin; Spinocerebellar ataxia 5 protein; SPTN2_HUMAN.

产品应用

应用已检合格种属预测种属推荐稀释比例

IHC-PHuman, RatMouse, Rabbit, Sheep, Cow, Dog1:100-500

IHC-FHuman, RatMouse, Rabbit, Sheep, Cow, Dog1:100-500

IFHuman, RatMouse, Rabbit, Sheep, Cow, Dog1:100-500

Not yet tested in other applications.

Optimal working dilutions must be determined by the end user.

交叉反应

Human, Rat (predicted: Mouse, Rabbit, Sheep, Cow, Dog)

抗体来源

Rabbit

免疫原

KLH conjugated synthetic peptide derived from human SPTBN2 : 71-170/2390

亚型

IgG

性状

Liquid

纯化方法

affinity purified by Protein A

克隆类型

Polyclonal

理论分子量

271 kDa

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

研究领域

Epigenetics and Nuclear Signaling > ChIP assays > ChIP kits

Neuroscience > Neurology process > Neurodegenerative disease

Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins

SWISS

O15020

Gene ID

6712

保存条件

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

背景资料

Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by ｆorming dimers, tetramers and higher polymers. Spectrin Alpha and spectrin Beta are present in erythrocytes, whereas spectrin Alpha II (also designated fodrin Alpha) and spectrin Beta I (also designated fodrin Beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin Beta III is highly homologous to both spectrin Beta I and spectrin Beta II. Western blot analysis shows that spectrin Beta III migrates at a higher molecular mass than predicted in the kidney. Spectrin Beta III is highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta. Specifically, spectrin Beta III constitutes a major component of the Golgi and vesicular membrane skeletons.