Highlighting the Advantages of NativeMP™ Copolymers for Cryo-EM Optimization

We’re excited to announce the release of a new application note showcasing how NativeMP™ copolymers from Cube Biotech are transforming membrane protein research for cryo-EM applications. This joint effort between Cube Biotech, NanoTemper, and the Imperiali Lab (MIT) presents a streamlined workflow that integrates dynamic light scattering (DLS) and nanoDSF technology for efficient copolymer screening.

The application note demonstrates how the NativeMP™ Screening Kit simplifies the solubilization and stabilization of challenging membrane proteins, ensuring optimal nanodisc formation and protein stability. By using DLS and nanoDSF with the Prometheus Panta, researchers can rapidly identify the best copolymers, reducing both time and material needed for high-resolution cryo-EM studies.

This work highlights the versatility and efficiency of NativeMP™ copolymers across a wide range of applications, including structural biology, enzyme assays, and drug discovery.

Visit our product page to explore how NativeMP™ can support your cryo-EM projects, and download the app note to learn more about this approach!

➡ Download Application Note
➡ Schedule a Meeting to learn more about the NativeMP™ technology