Two Ras-related human genes, designated RAP1A ａnd RAP1B, encode 95% homologous proteins (namely Rap 1A ａnd Rap 1B) that share a similar C-terminal Cys-Ali-Ali-Xaa sequence with Ras proteins ａnd are ubiquitously expressed in mammalian tissues. The putative "effector" domain of Ras proteins, whose integrity is required for cell transformation as well as interaction with the putative effector protein GAP, is conserved in both Rap 1 proteins. Rap 1A is thought to interfere with Ras effector function by binding to Ras GAP in a GTP-dependent manner without affecting Rap 1A GTPase activity. Rap 2, another Ras-related protein, shares 60% identity with Rap 1A ａnd exhibits a carboxy terminal CAAX motif ａnd two upstream cysteines similar to those of the H-Ras, K-Ras ａnd N-Ras proteins. In contrast with Rap 1A ａnd Rap 1B, overexpression of Rap 2 does not interfere with the Ras signaling pathway.
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Recombinant protein

WBFC

Human