DKK3, like DKK1, DKK2, ａnd DKK4, possesses an N-terminal signal peptide ａnd 2 conserved cysteine-rich domains, which are separated by a linker region ａnd contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, ａnd DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, ａnd spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, ａnd heart.1) Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
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This DKK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human DKK3.

IHC-PWB

Human