IRAK inhibitor 4 是白细胞介素-1 受体相关激酶-4 (IRAK4) 的抑制剂。
Abarelix产品描述：Abarelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment. In Vitro: Abarelix (30 ａnd 300 µg/mL) ａnd cetrorelix cause significantly increased histamine release^[1]. Abarelix is the first GnRH antagonist to be developed, ａnd can produce rapid ａnd sustained decreases in testosterone to castrate levels without the need for co-administration of an antiandrogen, ａnd with a very low complication rate in the short term^[2]. Abarelix demonstrates to promptly ａnd substantially reduce follicle-stimulating hormone levels to lower than LHRH agonist. Abarelix does not cause a surge in serum testosterone that can precipitate a flare phenomenon or worsening of disease, particularly dangerous for patients with metastatic, symptomatic disease, ａnd produces medical castration more quickly^[3].


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产品链接：www.medchemexpress.cn/Abarelix.html


Purity:98%
MWt:620.6646
Formula:C33H35F3N6O3
SMILES:OC1CCC(N2C3=C(C=C(C=C3)C(NCCC(C)C)=O)N=C2NC4=NNC5=C4C=C(C=C5)C6=CC=CC=C6OC(F)(F)F)CC1
Pathway:Immunology/Inflammation; Protein Tyrosine Kinase/RTK;
Mechanisms:IRAK;
Research Area:Inflammation/Immunology
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