(±)-雌马酚

CAS No. : 94105-90-5

MCE 国际站：(±)-Equol

产品活性：(±)-Equol 是 equol 的外消旋体。(±)-Equol 对 ERα 和 ERβ 的 EC₅₀s of 分别为 200 和 74 nM。Equol是大豆异黄酮黄豆苷和大豆黄素的代谢产物。

研究领域：Others | Metabolic Enzyme/Protease

作用靶点：Estrogen Receptor/ERR | Drug Metabolite

结构分类：酚类 | 多酚类 | 酚类 | 单酚类

来源：植物 | 豆科 | 大豆

In Vitro: Equol is first isolated ａnd identified from pregnant-mares＇ urine ａnd later found in the urine of the goat, cow, hen ａnd sheep. Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center ａnd therefore can occur as 2 distinct diastereoisomers. S-equol is the exclusive product of human intestinal bacterial synthesis from soy isoflavones ａnd both enantiomers are bioavailable. S-equol has a high affinity for estrogen receptor beta (K_i=0.73 nM), whereas R-equol is relatively inactive. Equol could promote the proliferation ａnd differentiation of rat osteoblasts through activating the ER-PKCα-related signaling pathway. The alkaline phosphatase activity also increases significantly in all of the equol ａnd 17β-estradiol (E2 ) groups. Equol also significantly elevates the osteocalcin levels.

In Vivo: Equol is a modest natriuretic ａnd vasorelaxant agent in the rat. Orally administered equol is about 8-fold less potent than orally administered furosemide. In isolated aortic rings precontracted by administration of phenylephrine, administration of equol relaxes the contracted aorta (concentration for half-maximal activity 58.9±16 μM). Equol possesses anticancer activity that suppresses tumor formation via apoptosis induction in rats with DMBA-induced mammary gland tumors. In addition, equol shows a hepatic protective effect by acting as an antioxidant ａnd by reducing apoptosis.

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