醋酸棉酚

CAS No. : 12542-36-8

MCE 国际站：Gossypol (acetic acid)

产品活性：Gossypol acetic acid ((±)-Gossypol-acetic acid) 分别与 Bcl-xL 蛋白和 Bcl-2 蛋白结合，K_i 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

结构分类：酚类 | 多酚类

来源：植物 | 其他科

In Vitro: Gossypol, a natural product isolated from cottonseeds ａnd roots that has been studied as an anticancer agent. The racemic form of Gossypol [(±)-Gossypol] is tested in several clinical trials ａnd is well tolerated. The racemic form Gossypol ((±)-Gossypol) binds to Bcl-xL protein with a K_i of 0.5 to 0.6 μM. (±)-Gossypol also potently binds to Bcl-2 protein with a K_i value of 0.2-0.3 mM. The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol ａnd (+)-Gossypol enantiomers. The racemic form ａnd each of the enantiomers of Gossypol are tested against UM-SCC-6 ａnd UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).

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