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4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine

MCE 国际站：4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine

品牌：MedChemExpress (MCE)

货号：HY-111513

CAS 号：566169-98-0

生物活性：4-(6-溴-2-苯并噻唑基)-N-甲基苯胺是一种强效的淀粉样蛋白成像剂，能与淀粉样蛋白β (1-40) 结合，KD 为 1.7 nM。

体内研究(In Vivo)：Alzhermer´s Disease (AD) is a neurodegenerative illness characterized by memory loss and other cognitive deficits. The ability to quantify amyloid load before treatment is critical to the efficient development of this class of drugs[2]. Brain entry in control mice and baboons is high for 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine. Staining of AD frontal cortex tissue sections with 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine indicates the selective binding of the compound to amyloid plaques and cerebrovascular amyloid. The encouraging properties of the compound support the choice of this derivative for further evaluation in human subject studies of brain Amyloid-βdeposition. The brain radioactivity concentrations (%ID-kg/g) of 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is remarkably similar in mice and baboons (0.21 vs 0.27). The rate of clearance of radioactivity is considerably slower from baboon brain than from mouse brain, although the rank order of clearance rate is similar in mice and baboons. The tissue staining findings utilizing nonradiolabeled, fluorescent 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine are similar to those reported for BTA-1. Both amyloid plaques and cerebrovascular amyloid are stained by 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine in a manner similar to serial sections stained with an antibody to Amyloid-β, and relatively little tissue background staining is observed[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：319.22

Formula：C14H11BrN2S

性状：固体

颜色：Light yellow to yellow

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式： 4°C，避光保存 *溶剂保存：-80°C，6个月；-20°C，1个月（避光保存）

Animal Administration [1]：Mice[1] Studies are performed in female Swiss-Webster mice (23-35 g). The mice are injected in a lateral tail vein with 0.37-3.7 MBq (10-100 µCi) of a high specific activity (>7.4 GBq/µmol) 11C-4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine contained in 11C standards prepared from the injection solution to determine the percent injected dose (%ID) in the samples. The brain samples are weighed to determine the percent injected dose per gram tissue (%ID/g), and this quantity is multiplied by the whole body weight (in kg) to determine the body-weight normalized radioactivity concentration [(%ID-kg)/g] of each tissue sample[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

提供质量检测报告：Data Sheet、SDS、COA、HNMR、LCMS、产品使用指南

产品活性：4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine是一种有效的淀粉样蛋白显像剂，其与淀粉样蛋白 Amyloid-β (1-40) 结合的 KD 值为1.7nM。

IC50 & Target：Ki: 1.7 nM (Amyloid-β)[1]

相关产品：Emrusolmin | Xanthocillin X permethyl ether | Glutaminyl Cyclase Inhibitor 1 | CRANAD-2 | Aftin-4 | BF 227 | Methoxy-X04 | Davunetide | Phenserine | Emrusolmin (Standard) | Miridesap | BF-168

热门产品线：抑制剂 | 稳定性同位素标记物 | 脂质 | 糖类

Trending products：Inhibitors | Isotope-Labeled Compounds | Lipids | Saccharides

参考文献：
[1]. Mathis CA, et al. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem. 2003 Jun 19;46(13):2740-54.
[2]. Klunk W, et al. Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies.