Anti-CaMK2a, 钙/钙调素依赖蛋白激酶2α抗体

• Product nameAnti-CAMK2A + CAMK2B + CAMK2D antibody
• Description
  Rabbit polyclonal to CAMK2A + CAMK2B + CAMK2D
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide derived from an internal region of Human CAMK2A + CAMK2B + CAMK2D.

• Positive controlHuman brain tissue

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferpH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
• Concentration100 µg at 1 mg/ml
  
• PurityImmunogen affinity purified
• ClonalityPolyclonal
• IsotypeIgG
• Research Areas
  • Neuroscience
  • Neurotransmission
  • Calcium Signaling
  • Calmodulin / CaMK

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Calmodulin Pathway

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Other

Applications

Target

• RelevanceCa2+/Calmodulin Dependent Protein Kinase II （CaM Kinase II） is a multifunctional calcium ａnd calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis ａnd release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, ａnd Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD ａnd reduce LTP ａnd learning.
• Database links
  • Entrez Gene: 815 Human
  • Entrez Gene: 816 Human
  • Entrez Gene: 817 Human
  • Entrez Gene: 108058 Mouse
  • Entrez Gene: 12322 Mouse
  • Entrez Gene: 12323 Mouse
  • Entrez Gene: 24245 Rat
  • Entrez Gene: 24246 Rat

  see all
• Alternative names
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody
  • Calcium/calmodulin-dependent protein kinase type II subunit delta antibody
  • CaM kinase II subunit alpha antibody

  see all

Anti-CAMK2A + CAMK2B + CAMK2D antibody images

• 

  Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - CAMK2A + CAMK2B + CAMK2D antibody （ab110881）
  ab110881, at a 1/50 dilution, staining CAMK2A + CAMK2B + CAMK2D in paraffin-embedded Human brain tissue by Immunohistochemistry, in the absence （left panel） or presence （right panel） of the immunizing peptide.

References for Anti-CAMK2A + CAMK2B + CAMK2D antibody （ab110881）