Anti-Amylin ，糖尿病相关肽/胰岛淀粉样肽抗体

• Product nameAnti-Amylin antibody [R10/99]See all Amylin primary antibodies ...
• Description
  Mouse monoclonal [R10/99] to Amylin
• Tested applicationsIHC-Fr, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Cat, Dog, Chinese Hamster
• Immunogen

  Synthetic peptide: CATQRLANFLV, corresponding to amino acids 40-50 of Human Amylin coupled to tuberculin.

  Run BLAST with Run BLAST with
• Positive controlHuman Pancreas, Islet of Langerhans

Properties

• FormLiquid
• Storage instructionsStore at 4°C or at -20°C for long term storage.
• Storage bufferPreservative: 0.09% Sodium azide
• PurityTissue culture supernatant
• ClonalityMonoclonal
• Clone numberR10/99
• IsotypeIgG1
• Research Areas
  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

  • Metabolism
  • Pathways ａnd Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Types of disease
  • Diabetes

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Types of disease
  • Heart disease

Applications

Target

• FunctionSelectively inhibits insulin-stimulated glucose utilization ａnd glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
• Sequence similaritiesBelongs to the calcitonin family.
• DomainThe mature protein is largely unstructured in the absence of a cognate ligand, ａnd has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.
• Post-translational
  modificationsAmyloid fibrils are degraded by IDE.
• Cellular localizationSecreted.
• Information by UniProt
• Database links
  • Entrez Gene: 751513 Cat
  • Entrez Gene: 3375 Human
  • Entrez Gene: 15874 Mouse
  • Entrez Gene: 100009489 Rabbit
  • Entrez Gene: 24476 Rat
  • Omim: 147940 Human
  • SwissProt: P12967 Cat
  • SwissProt: P10997 Human

  see all
• Alternative names
  • Amylin antibody
  • DAP antibody
  • Diabetes associated peptide antibody

  see all

Anti-Amylin antibody [R10/99] images

• 

  Immunohistochemistry （Formalin/PFA-fixed paraffin-embedded sections） - Anti-Amylin antibody [R10/99] （ab115766）
  ab115766, at 1/100 staining Amylin in formalin fixed, paraffin embedded Human Pancreas, Islet of Langerhans by Immunohistochemistry. Developed using biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase streptavidin ａnd chromogen.

References for Anti-Amylin antibody [R10/99] （ab115766）