Anti-ABCB6，ABCB6抗体

• Product nameAnti-ABCB6 antibody
• Description
  Rabbit polyclonal to ABCB6
• Tested applicationsICC/IF, ELISA, WB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide: RAMNTQENATRARAVD, corresponding to internal sequence amino acids 440-455 of Human ABCB6

  Run BLAST with Run BLAST with
• Positive controlKB cells transfected with the ABCB6 protein.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot ａnd store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Sodium Azide
  Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
• Concentration100 µg at 1 mg/ml
  
• PurityImmunogen affinity purified
• ClonalityPolyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Hypoxia
  • Hypoxia-Regulated

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Cancer
  • Drug resistance
  • P glycoproteins

  • Metabolism
  • Pathways ａnd Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways ａnd Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Types of disease
  • Cancer

Applications

• Application notesELISA: 1/40000 - 1/200000.
  IF （microscopy）: Use at an assay dependent dilution.
  WB: 1/1000 - 1/5000. Predicted molecular weight: 93 kDa.
  
  
  Not yet tested in other applications.
  Optimal dilutions/concentrations should be determined by the end user.

Target

• FunctionBinds heme ａnd porphyrins ａnd functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
• Tissue specificityWidely expressed. Highest expression in heart ａnd skeletal muscles.
• Sequence similaritiesBelongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer （TC 3.A.1.210） subfamily.
  Contains 1 ABC transmembrane type-1 domain.
  Contains 1 ABC transporter domain.
• Developmental stageHighly expressed in fetal liver.
• Cellular localizationMitochondrion outer membrane.
• Information by UniProt
• Database links
  • Entrez Gene: 10058 Human
  • Entrez Gene: 74104 Mouse
  • Entrez Gene: 140669 Rat
  • Omim: 605452 Human
  • SwissProt: Q9NP58 Human
  • SwissProt: Q9DC29 Mouse
  • SwissProt: O70595 Rat
  • SwissProt: Q9Z1S2 Rat

  see all
• Alternative names
  • ABC antibody
  • ABC transporter umat antibody
  • ABC14 antibody

  see all

Anti-ABCB6 antibody images

• 

  Western blot - ABCB6 antibody （ab47837）
  All lanes : Anti-ABCB6 antibody （ab47837） at 1/1400 dilution
  
  Lane 1 : KB cell lysate expressing Flag™-tagged human ABCB6 protein
  Lane 2 : KB cell lysate without a vector insert
  
  
  Predicted band size : 93 kDa
  Observed band size : 104 kDa （why is the actual band size different from the predicted?）
  Additional bands at : 79 kDa （possible truncated form）.

References for Anti-ABCB6 antibody （ab47837）