Anti-AATF， 拮抗凋亡转录因子抗体

• Product nameAnti-AATF antibodySee all AATF primary antibodies ...
• Description
  Rabbit polyclonal to AATF
• Tested applicationsWB, IHC-P, ICC/IF more details
• Species reactivity
  Reacts with: Mouse, Human
• Immunogen

  A 12 amino acid synthetic peptide from near the carboxy terminus of human AATF.

• Positive controlHuman small intestine cell lysate.

Properties

• FormLiquid
• Storage instructionsStore at +4°C.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration100 µg at 1 mg/ml
  
• PurityImmunogen affinity purified
• ClonalityPolyclonal
• IsotypeIgG
• Research Areas
  • Cell Biology
  • Apoptosis
  • Intracellular
  • Survivin / IAPs

  • Epigenetics ａnd Nuclear Signaling
  • Transcription
  • Other factors

Applications

Target

• FunctionMay function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes ａnd cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor ａnd blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease （presenile ａnd senile dementia）, although the molecular basis for this phenomenon has not been described to date.
• Tissue specificityUbiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta ａnd thymus.
• Sequence similaritiesBelongs to the AATF family.
• Post-translational
  modificationsHyperphosphorylated during the G1/S phase transition.
• Cellular localizationNucleus > nucleolus.
• Information by UniProt
• Database links
  • Entrez Gene: 26574 Human
  • Entrez Gene: 56321 Mouse
  • Omim: 608463 Human
  • SwissProt: Q9NY61 Human
  • SwissProt: Q3URN5 Mouse
  • SwissProt: Q9JKX4 Mouse
  • Unigene: 195740 Human
  • Unigene: 257482 Mouse
• Alternative names
  • AATF antibody
  • AATF_HUMAN antibody
  • Apoptosis antagonizing transcription factor antibody

  see all

Anti-AATF antibody images