Anti-TBR1TBR1蛋白抗体

本公司经销TBR1，TBR1蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，TBR1TBR1蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11603R
英文名称：Anti-TBR1
中文名称：TBR1蛋白抗体
其他名称：名A novel murine ａnd human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury （T） gene that is expressed only in postmitotic cells. T-brain-1 （TBR-1） mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex ａnd neocortex （1-3）. TBR-1, Pax-6 ａnd Emx-1 are expressed in the mouse ａnd chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 ａnd Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse ａnd chicken may have similar histogenetic specification processes ａnd field homologies （4）. CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization ａnd signaling. In adult rat brain, CASK is concentrated at neuronal synapses ａnd binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus ａnd binds to a specific DNA sequence （the T-element） in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin （5）.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 74kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：A novel murine ａnd human gene, TBR-1, encodes a putative transcription factor related to the Brachyrury （T） gene that is expressed only in postmitotic cells. T-brain-1 （TBR-1） mRNA is largely restricted to the cerebral cortex, where, during embryogenesis, it defines different regions that give rise to the palecortex, limbic cortex ａnd neocortex （1-3）. TBR-1, Pax-6 ａnd Emx-1 are expressed in the mouse ａnd chicken pallium. The pallio-subpallial boundary lies at the interface between the TBR-1 ａnd Dlx-2 expression domains. Chicken genes homolgous to these mouse genes are expressed in topologically comparable patterns during development, suggesting that mouse ａnd chicken may have similar histogenetic specification processes ａnd field homologies （4）. CASK/LIN-2, a membrane-associated guanylate kinase, is required for EGFR localization ａnd signaling. In adult rat brain, CASK is concentrated at neuronal synapses ａnd binds to the cell-surface proteins. CASK can interact with TBR-1, which is involved in forebrain development. CASK enters into the nucleus ａnd binds to a specific DNA sequence （the T-element） in a complex with TBR-1. Thus, CASK acts as a coactivator of TBR-1 to induce transcription of T-element containing genes, including reelin （5）.Function : T box brain 1 （TBR1） is a member of a conserved protein family that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Disruption of the mouse TBR1 homolog demonstrated a critical role for TBR1 in early cortical development. TBR1 expression is largely restricted to the cerebral cortex, where during embryogenesis it distinguishes domains that give rise to the paleocortex, limbic cortex, ａnd neocortex. Subcellular Location : Nuclea