Anti-phospho-TNIK(Ser764)磷酸化TRAF2和NCK激酶相互作用蛋白抗体

本公司经销phospho-TNIK（Ser764），磷酸化TRAF2和NCK激酶相互作用蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-TNIK（Ser764）磷酸化TRAF2和NCK激酶相互作用蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5598R
英文名称：Anti-phospho-TNIK（Ser764）
中文名称：磷酸化TRAF2和NCK激酶相互作用蛋白抗体
其他名称：名Traf2 ａnd NCK interacting kinase; 1500031A17RIK; 4831440I19RIK; AI451411; C530008O15Rik; C630040K21RIK; KIAA0551; MGC189819; MGC189859; RGD1561817; TNIK.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 150kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, pig, dog
产品介绍：TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 （TRAF2） ａnd the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when over expressed in Phoenix-A cells. TNIK has been shown to phosphorylate gelsolin, the principal intracellular ａnd extracellular actin-severing protein, in vitro. This ａnd evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton. Northern analysis indicates TNIK expression in human heart, skeletal muscle, ａnd brain, with lower levels of expression in kidney, liver, lung, ａnd pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder ａnd skin.Function : Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes ａnd required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A ａnd TNIK which regulates neuronal dendrite extension ａnd arborization during development. More generally, it may play a role in cytoskeletal rearrangements ａnd regulate cell spreading. Phosphorylates SMAD1 on Thr-322.Subunit : Interacts （via the CNH domain） with RAP2A （GTP-bound form preferentially）; the interaction is direct ａnd required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 ａnd NCK. Interacts with TCF7L2/TCF4 ａnd CTNNB1; the interaction is direct. Interacts with TANC1.Subcellular Location : Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes ａnd the cytoskeletal fraction upon RAP2A overexpression.Tissue Specificity : Expressed ubiquitously. Highest levels observed in heart, brain ａnd skeletal muscle. Expressed in normal colonic epithelia ａnd colorectal cancer tissues.Post-translational modifications : Autophosphorylated. Autophosphorylation is activated by RAP2A ａnd induces association to the cytoskeletal fraction.Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CNH domain. Contains 1 protein kinase domain.