Anti-TGFβ1转化生长因子β1抗体

本公司经销TGFβ1，转化生长因子β1抗体，克隆类型为polyclonal，宿主来源是Rabbit，TGFβ1转化生长因子β1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0086R
英文名称：Anti-TGFβ1
中文名称：转化生长因子β1抗体
其他名称：名TGF Beta 1; TGF β1; TGF-β1;TGFβ2; TGFβ3; CED; Diaphyseal dysplasia 1 progressive; DPD 1; DPD1; TGF beta 1; TGF beta; TGF beta1; TGF beta2; TGF beta3; TGFB 1; TGFB; TGFB1; TGFB2; TGFB3; Transforming growth factor; Transforming growth factor beta 1; Transforming growth factor beta 2; Transforming growth factor beta 3; Transforming Growth Factor beta.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 12.8kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, shp, Rb, pig, dog, Gpig
产品介绍：This gene encodes a member of the transforming growth factor beta （TGFB） family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, ａnd other functions in many cell types. Many cells have TGFB receptors, ａnd the protein positively ａnd negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide （LAP） ａnd a mature TGFB1 peptide, ａnd is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, ａnd a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form composed of a TGFB1 homodimer. The mature peptide may also form composed of a TGFB1 homodimer. The mature peptide may also form composed of a TGFB1 homodimer. The mature peptide may also form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, ａnd mutations in this gene result in Camurati-Engelmann disease.Function : Multifunctional protein that controls proliferation, differentiation ａnd other functions in many cell types. Many cells synthesize TGFB1 ａnd have specific receptors for it. It positively ａnd negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation ａnd differentiation in committed osteoblasts.Subunit : Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted ａnd stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex （large latent TGF-beta1 complex） containing the TGFB1 homodimer, the latency-associated peptide （LAP）, ａnd the latent TGFB1 binding protein-1 （LTBP1）. The complex without LTBP1 is known as the＇small latent TGF-beta1 complex＇. Dissociation of the TGFB1 from LAP is required for growth factor activation ａnd biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3 （By similarity）. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly ａnd attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 ａnd HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition （By similarity）. Interacts with CD109, DPT ａnd ASPN.Subcellular Location : Secreted, extracellular space, extracellular matrix.Tissue Specificity : Highly expressed in bone. Abundantly expressed in articular cartilage ａnd chondrocytes ａnd is increased in osteoarthritis （OA）. Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.Post-translational modifications : Glycosylated. The precursor is cleaved into mature TGF-beta-1 ａnd LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.DISEASE : Defects in TGFB1 are the cause of Camurati-Engelmann disease （CE） [MIM:131300]; also known as progressive diaphyseal dysplasia 1 （DPD1）. CE is an autosomal dominant disorder characterized by hyperostosis ａnd sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness ａnd waddling gait, ａnd in some cases other features such as exophthalmos, facial paralysis, hearing difficulties ａnd loss of vision.Similarity : Belongs to the TGF-beta family.生长因子和激素（ Growth Factor ａnd Hormones）TGF是一种多效生长因子，对上皮细胞增值有潜在抑制作用，可抑制肿瘤生长用于许多恶性肿瘤如:胃癌、肺癌、膀胱癌、肾癌、前列腺癌、结肠癌等多种恶性肿瘤的研究。TGFβ超级家族由为数众多的生长的分化因子组成，包括转移生长因子β1，2和3（TGF β1，TGF β2，TGF β3）；胎盘生长因子（PTGF-β）；生长/分化因子（GDFs）；缪氏抑制物（MIS）；骨形态形成蛋白（BMPs）；交织细胞元神经生长因子（GDNF）；抑制素和活化素（α, β-A,和β-C），Lefty和Nodal。TGF超级家族成员参与胚胎发育和成体组织体内平衡。TGF-β1抗体与TGF-β2和TGF-β3没有交叉反应。与豚鼠有大部分交叉。产品图片Tissue/cell: human flat moss tinea; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-TGF-beta-1 Polyclonal Antibody, Unconjugated（bs-0086R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingTissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-TGF-beta-1 Polyclonal Antibody, Unconjugated（bs-0086R） 1:300, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingProtein: line1, mouse brain lysates, 20ug; line2, mouse liver lysates, 20ug; Primary: Anti-TGF-beta-1 （bs-0086R） at 1:300; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 3000; ECL excitated the fluorescence; Predicted band size : 12.8kDObserved band size : 15kD