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Anti-TPA/PLAT组织型纤溶酶原激活剂抗体
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价格：￥电议
更新日期：2026/9/8 4:13:22
生 产 地：其它
产品型号：BY-1545R
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相关标签：TPA/PLAT,组织型纤溶酶原激活剂抗体,TPA/PLAT组织型纤溶酶原激活剂
详细内容
本公司经销TPA/PLAT，组织型纤溶酶原激活剂抗体，克隆类型为polyclonal，宿主来源是Rabbit，TPA/PLAT组织型纤溶酶原激活剂抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-1545R
英文名称：Anti-TPA/PLAT
中文名称：组织型纤溶酶原激活剂抗体
其他名称：名TPA Tissue Plasminogen Activator; Plasminogen activator tissue; Plasminogen activator tissue type; Plasminogen Activator Tissue Type Isoform 1 Preproprotein; PLAT; Reteplase; t PA; t-PA; T Plasminogen Activator; Tissue plasminogen activator （t PA）; PATISS; Tissue type plasminogen activator; TPA; TPA1; AU020998; AW212668; D8Ertd2e; MGC18508.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 62kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, pig, cow, hrs, Rb
产品介绍：TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling ａnd degradation, cell migration ａnd many other physiopathological events. TPA binds to fibrin with high affinity; this leads to an increase in the catalytic efficiency of the enzyme of 100- to 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binding to laminin ａnd fibronectin has also been demonstrated. TPA also binds to mannose receptor ａnd the low density lipoprotein receptor related protein （LRP1）. These proteins are involved in TPA clearance. TPA binds to annexin II ａnd to cytokeratin 8. As yet unidentified interactions on endothelial cells ａnd vascular smooth muscle cells （VSMC） lead to a 100-fold stimulation of plasminogen activation. Binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.Subcellular Location : Secreted.Tissue Specificity : Synthesized in numerous tissues （including tumors） ａnd secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, ａnd milk.组织型纤溶酶原激活剂tPA是丝氨酸蛋白酶家族的一员,其主要的生物学功能是激活纤溶酶原转变为纤溶酶.近年来经研究表明t-PA参与循环系统的溶血栓过程之外,t-PA还在神经系统中也发挥了重要的作用，t-PA参与了癫痫和早老型痴呆症等神经系统疾病的发生和发展，在学习和记忆等生理过程中也发挥了重要作用。
货号：BY-1545R
英文名称：Anti-TPA/PLAT
中文名称：组织型纤溶酶原激活剂抗体
其他名称：名TPA Tissue Plasminogen Activator; Plasminogen activator tissue; Plasminogen activator tissue type; Plasminogen Activator Tissue Type Isoform 1 Preproprotein; PLAT; Reteplase; t PA; t-PA; T Plasminogen Activator; Tissue plasminogen activator （t PA）; PATISS; Tissue type plasminogen activator; TPA; TPA1; AU020998; AW212668; D8Ertd2e; MGC18508.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 62kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, pig, cow, hrs, Rb
产品介绍：TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling ａnd degradation, cell migration ａnd many other physiopathological events. TPA binds to fibrin with high affinity; this leads to an increase in the catalytic efficiency of the enzyme of 100- to 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binding to laminin ａnd fibronectin has also been demonstrated. TPA also binds to mannose receptor ａnd the low density lipoprotein receptor related protein （LRP1）. These proteins are involved in TPA clearance. TPA binds to annexin II ａnd to cytokeratin 8. As yet unidentified interactions on endothelial cells ａnd vascular smooth muscle cells （VSMC） lead to a 100-fold stimulation of plasminogen activation. Binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.Subcellular Location : Secreted.Tissue Specificity : Synthesized in numerous tissues （including tumors） ａnd secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, ａnd milk.组织型纤溶酶原激活剂tPA是丝氨酸蛋白酶家族的一员,其主要的生物学功能是激活纤溶酶原转变为纤溶酶.近年来经研究表明t-PA参与循环系统的溶血栓过程之外,t-PA还在神经系统中也发挥了重要的作用，t-PA参与了癫痫和早老型痴呆症等神经系统疾病的发生和发展，在学习和记忆等生理过程中也发挥了重要作用。
TPA/PLAT,组织型纤溶酶原激活剂抗体,TPA/PLAT组织型纤溶酶原激活剂
