Anti-phospho-PAK1/2/3(Thr423)磷酸化p21激活激酶1/2/3抗体

本公司经销phospho-PAK1/2/3（Thr423），磷酸化p21激活激酶1/2/3抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-PAK1/2/3（Thr423）磷酸化p21激活激酶1/2/3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1652R
英文名称：Anti-phospho-PAK1/2/3（Thr423）
中文名称：磷酸化p21激活激酶1/2/3抗体
其他名称：名phospho-PAK1（pSer144）+Anti-phospho-PAK2（pSer141）+Anti-phospho-PAK3（pSer139）; Alpha PAK; Beta PAK; Gamma PAK; Oligophrenin 3; OPHN3; p21 activated kinase 1; p21 Activated Kinase 1 + 2 + 3; p21 activated kinase 2 ; p21 activated kinase 3; P65 PAK; PAK1; PAK2; PAK3; PAK3beta; PAK65; PAKalpha; PAKgamma; S6/H4 kinase; Serine/threonine protein kinase PAK 1; Serine/threonine protein kinase PAK 2; Serine/threonine protein kinase PAK 3; Serine/threonine protein kinase PAK1; Serine/threonine protein kinase PAK2; Serine/threonine protein kinase PAK3.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, Rb, chk, dog, cow
产品介绍：The p21 activated kinases （PAK） are critical effectors that link Rho GTPases to cytoskeleton reorganization ａnd nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 ａnd RAC1, ａnd have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, ａnd may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase （PAK） is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, ａnd PAK 3 （also known as alpha PAK, gamma PAK, ａnd beta PAK, respectively）. These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 （SH3） domains, ａnd caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 （serine 144 for PAK 1 ａnd serine 139 PAK 3）, catalyzed by Cdc42, is required for activation of PAK.Function : The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 ａnd RAC1. Involved in dissolution of stress fibers ａnd reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. DVL1 ａnd PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction （NMJ）. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 ａnd CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at ＇Ser-338＇ ａnd ＇Ser-339＇ resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, ａnd RAF1 binding to BCL2.Subunit : Homodimer in its autoinhibited state. Active as monomer. Interacts tightly with GTP-bound but not GDP-bound CDC42/P21 ａnd RAC1. Binds to the caspase-cleaved p110 isoform of CDC2L1 ａnd CDC2L2, p110C, but not the full-length proteins. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 ａnd GIT1. Interacts with ARHGEF7. Also interacts with CRIPAK. Interacts with NISCH. Interacts with DVL1; mediates the formation of a DVL1, MUSK ａnd PAK1 ternary complex involved in AChR clustering. Probably found in a ternary complex composed of DSCAM, PAK1 ａnd RAC1. Interacts with DSCAM （via cytoplasmic domain）; the interaction is direct ａnd enhanced in presence of RAC1. Interacts with SCRIB. Interacts with PDPK1. Interacts （via kinase domain） with RAF1. Interaction with NCK1 ａnd NCK2.Subcellular Location : Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions upon activation.Post-translational modifications : Autophosphorylated when activated by CDC42/p21 ａnd RAC1. Phosphorylation at Thr-423 by PDPK1 results in its activation.Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CRIB domain. Contains 1 protein kinase domain.Database links : UniProtKB/Swiss-Prot: Q13153.2PAK1-3蛋白具有广泛的生物学功能,也是一个保守的丝氨酸/苏氨酸蛋白激酶,参与许多重要的细胞活动。包括细胞骨架的动力学调节,细胞移动,生存和凋亡,细胞周期,基因转录调节,细胞生长信号转导和转化等。