联系我们
联系人：王羽
产品展示
Anti-PEG3PEG3蛋白抗体
点击次数：156
价格：￥电议
更新日期：2026/9/8 4:13:14
生 产 地：其它
产品型号：BY-1870R
商家名片
王*
联系我时，请说明是阿仪网看到的，谢谢!
- 电话: 02*******064
- 手机: 18******406
- 微信:
- 交换名片后展示联系方式 → →
相关标签：PEG3,PEG3蛋白抗体,PEG3PEG3蛋白抗体
详细内容
本公司经销PEG3，PEG3蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，PEG3PEG3蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！
货号：BY-1870R
英文名称：Anti-PEG3
中文名称：PEG3蛋白抗体
其他名称：名Paternally-expressed gene 3 protein; Zinc finger ａnd SCAN domain-containing protein 24; Kruppel-type zinc finger protein; paternally expressed 3; Paternally expressed gene 3; PEG3 protein; Pw1; Zn-finger protein Pw1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 175kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow
产品介绍：In human, ZIM2 ａnd PEG3 are treated as two distinct genes though they share multiple 5＇ exons ａnd a common promoter ａnd both genes are paternally expressed （PMID:15203203）. Alternative splicing events connect their shared 5＇ exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, ａnd likely other mammals as well, the ZIM2 ａnd PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation ａnd p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity ａnd tumorigenesis in glioma ａnd ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.Function : Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 ａnd BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 ａnd inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.Subunit : Homodimer. Interacts with SIAH1A ａnd SIAH2. Interacts with TRAF2.Subcellular Location : Nucleus. Cytoplasm.Tissue Specificity : Brain, glial cells, astrocytes, embryo, placenta, testis, ovary ａnd uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.Similarity : Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 12 C2H2-type zinc fingers.Contains 1 SCAN box domain.PEG3蛋白是一种转录因子。在胰腺、脑组织、胎盘、卵巢、睾丸等组织中表达，PEG3蛋白位于细胞核内。PEG3也是一个凋亡促进因子并可能参与调节肿瘤坏死因子（TNF）信号传导通路。
货号：BY-1870R
英文名称：Anti-PEG3
中文名称：PEG3蛋白抗体
其他名称：名Paternally-expressed gene 3 protein; Zinc finger ａnd SCAN domain-containing protein 24; Kruppel-type zinc finger protein; paternally expressed 3; Paternally expressed gene 3; PEG3 protein; Pw1; Zn-finger protein Pw1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 175kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow
产品介绍：In human, ZIM2 ａnd PEG3 are treated as two distinct genes though they share multiple 5＇ exons ａnd a common promoter ａnd both genes are paternally expressed （PMID:15203203）. Alternative splicing events connect their shared 5＇ exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, ａnd likely other mammals as well, the ZIM2 ａnd PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation ａnd p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity ａnd tumorigenesis in glioma ａnd ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.Function : Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 ａnd BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 ａnd inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.Subunit : Homodimer. Interacts with SIAH1A ａnd SIAH2. Interacts with TRAF2.Subcellular Location : Nucleus. Cytoplasm.Tissue Specificity : Brain, glial cells, astrocytes, embryo, placenta, testis, ovary ａnd uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.Similarity : Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 12 C2H2-type zinc fingers.Contains 1 SCAN box domain.PEG3蛋白是一种转录因子。在胰腺、脑组织、胎盘、卵巢、睾丸等组织中表达，PEG3蛋白位于细胞核内。PEG3也是一个凋亡促进因子并可能参与调节肿瘤坏死因子（TNF）信号传导通路。
PEG3,PEG3蛋白抗体,PEG3PEG3蛋白抗体
