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文献引用产品：补体C3抗体
点击次数：93发布时间：2026/9/16 16:08:55
补体C3抗体文章标题：Ginsenoside Rg1 alleviates lupus nephritis by inhibiting complement activation in MRL/lpr mice
作者列表：Kerong Jiang, Limin Yin, Yongsheng Pan, Lijuan Shi
发表时间：2026-2-12
期刊：Journal of Radiation Research and Applied Sciences
影响因子：2.5
DOI:10.1016/j.jrras.2026.102231
主要研究成果：Abstract
Objective
Lupus nephritis (LN) is a major cause of kidney damage in patients with systemic lupus erythematosus (SLE). This study evaluates the therapeutic effects of ginsenoside Rg1, a bioactive ginseng compound, with emphasis on its regulation of complement activation in LN.
Methods
MRL/lpr mice were divided into model and Rg1-treated groups(50 or 100 mg/kg/day) for 5 weeks, while C57BL/6J mice served as normal controls. Renal function, autoantibody levels, and histopathological changes were analyzed. The expression of complement components (CFB, C3, C5, C5b-9) were analyzed by Western blotting and immunohistochemistry. A correlation analysis was performed to evaluate the relationship between renal C5b-9 deposition and proteinuria.
