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文献引用产品：人肝内胆管上皮细胞
点击次数：154发布时间：2025/12/24 17:12:38
文章标题：Forkhead box M1 recruits FoxP3+ Treg cells to induce immune escape in hilar cholangiocarcinoma
期刊：Immunity Inflammation and Disease
作者列表：Kai Ma, Zhaowei Sun, Xueliang Li, Jingyun Guo, Qinlei Wang, Mujian Teng
发表时间：2022-10-26
影响因子：2.493
DOI:10.1002/iid3.727
主要研究成果Abstract
Objective
Hilar cholangiocarcinoma (HCCA) is a malignancy related to chronic biliary tract inflammation. Tumor immune escape is a necessary process of tumorigenesis. Forkhead box M1 (FoxM1) could affect the progression of various carcinomas. This study attempted to elaborate on the mechanism of FoxM1 in HCCA immune escape.
Methods
HCCA cell lines were collected to measure the expression of FoxM1 and FoxP3. CD8+ T cells were extracted to establish the co-culture system with HCCA cells and Treg cells. pcDNA3.1-FoxM1 or si-FoxP3 was transfected into HCCA cells in the co-culture system. HCCA cell viability, mobility, and invasiveness as well as levels of transforming growth factor (TGF)-β and interleukin (IL)-6 were evaluated. The binding relation between FoxM1 and FoxP3 promoter was verified. HCCA cells with pcDNA3.1-FoxM1 were subcutaneously injected into mice to establish the xenograft mouse models.
