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雌激素受体α抗体0122
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品牌名称：$brandModel.Title型号：0122 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
中文名称雌激素受体α抗体
别 名Estradiol receptor; Estrogen receptor alpha; Estradiol Receptor-alpha; Estrogen Receptor 1; Atherosclerosis, susceptibility to, included; DKFZp686N23123; ER Alpha; ER; ER-alpha; ERalpha; ER[a]; Era; ESR; ESR1; ESR1_HUMAN; ESR2; ESRA; Estr; Estrogen receptor 1 (alpha); Estrogen resistance, included; HDL cholesterol, augmented response of, to hormone replacement, included; Myocardial infarction, susceptibility to, included; NR3A1; Nuclear receptor subfamily 3 group A member 1; OTTHUMP00000017718; OTTHUMP00000017719; RNESTROR.
研究领域 肿瘤 免疫学 生长因子和激素
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat, (predicted: Mouse, Dog, Cow, Rabbit, )
产品应用 WB=1:500-2000 ELISA=1:500-1000 ICC=1:100
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
细胞定位 细胞核
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human Estrogen Receptor alpha:331-360/595
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 Estrogen and progesterone receptor are members of a family of tranｓcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters tranｓcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two ｆorms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct ｆorms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a tranｓcriptional activator of progesterone-responsive gene, whereas hPR-A function as a tranｓcriptional inhibitor of all steroid hormone receptors.
Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
Subunit:
Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can ｆorm a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of tranｓcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated tranｓcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoｆorm 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances tranｓcriptional activity.
Glycosylated; contains N-acetylglucosamine, probably O-linked.
Similarity:
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
SWISS:
P06211
Gene ID:
2099
Database links:
Entrez Gene: 407238 Cow
Entrez Gene: 403640 Dog
Entrez Gene: 2099 Human
Entrez Gene: 13982 Mouse
Entrez Gene: 24890 Rat
Omim: 133430 Human
SwissProt: P49884 Cow
SwissProt: P03372 Human
热门标签：雌激素受体α抗体,雅吉抗体,一抗
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