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骨骼肌慢肌肌钙蛋白T抗体10616R
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品牌名称：$brandModel.Title型号：10616R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
中文名称骨骼肌慢肌肌钙蛋白T抗体
别 名Troponin T slow skeletal muscle; TNNT1; TNNT1_HUMAN; Troponin T, slow skeletal muscle; TnTs; Slow skeletal muscle troponin T; sTnT; ANM; MGC104241; Slow skeletal muscle troponin T; sTnT.
抗体来源Rabbit
克隆类型Polyclonal
交叉反应(predicted: Human, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量33kDa
细胞定位细胞浆
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TNNT1: 151-250/278
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple tranｓcript variants encoding different isoｆorms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
DISEASE:
Nemaline myopathy 5 (NEM5) [MIM:605355]: A ｆorm of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 5 is a severe and progressive ｆorm common among Old Order Amish. Affected infants display tremors with hypotonia and mild contractures of the shoulders and hips. Proximal contractures progressively weaken and a pectus carinatum deｆormity develops before children die of respiratory insufficiency, usually in the second year. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the troponin T family.
SWISS:
P13805
热门标签：骨骼肌慢肌肌钙蛋白T抗体,抗体
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