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生长抑制DNA损伤基因45抗体1360
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品牌名称：$brandModel.Title型号：1360 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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中文名称生长抑制DNA损伤基因45抗体
别 名Growth Arrest And DNA Damage Inducible Alpha; DNA Damage-Inducible Tranｓcript 1 Protein; DDIT-1; GADD45; DDIT1; Growth Arrest And DNA Damage-Inducible Protein GADD45 Alpha; Growth Arrest And DNA-Damage-Inducible 45 Alpha; Growth Arrest And DNA-Damage-Inducible, Alpha; DNA Damage-Inducible Tranｓcript-1; GA45A_HUMAN
研究领域 免疫学 信号转导 细胞凋亡 细胞周期蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, (predicted: Chicken, Pig, Cow, )
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
细胞定位 细胞浆 细胞膜
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GADD45:65-165/165
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This gene is a member of a group of genes whose tranｓcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced tranｓcription of this gene is mediated by both p53 dependent and independent mechanisms.
Function:
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.
Subunit:
Interacts with MAPK14. Predominantly monomeric but also ｆorms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the GADD45 family.
SWISS:
P24522
Gene ID:
1647
Database links:
Entrez Gene: 1647 Human
Entrez Gene: 13197 Mouse
Entrez Gene: 25112 Rat
Omim: 126335 Human
SwissProt: P24522 Human
SwissProt: P48316 Mouse
SwissProt: P48317 Rat
Unigene: 80409 Human
Unigene: 72235 Mouse
Unigene: 10250 Rat
热门标签：生长抑制DNA损伤基因45抗体,雅吉抗体,一抗
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