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G蛋白偶联受体75抗体1469
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详细内容
中文名称 G蛋白偶联受体75抗体
别 名 G protein-coupled receptor75; 75 kDa glucose regulated protein; 75 kDa glucose-regulated protein; CSA; Glucose Regulated Protein; Grp 75; GRP75; Heat shock 70kD protein 9; heat shock 70kDa protein 9; Heat shock 70kDa protein 9B; Heat shock protein 74 kDa A; Heat shock protein A; Heat shock protein cognate 74; Hsc74; Hsp74; Hsp74a; HSPA9; Hspa9a; HSPA9B; MGC4500; Mortalin 2; Mortalin; Mortalin perinuclear; Mortalin2; MOT 2; MOT; MOT2; Mthsp70; p66 mortalin; P66 MOT; PBP74; Peptide binding protein 74; Stress 70 protein mitochondrial; Stress 70 protein mitochondrial precursor.
研究领域 肿瘤 免疫学 信号转导 细胞膜受体 转运蛋白 G蛋白偶联受体 新陈代谢 G蛋白信号
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
细胞定位 细胞核 细胞浆
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRP75:561-679/679
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.
Function:
Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.
Subunit:
Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2.
Subcellular Location:
Mitochondrion. Nucleus, nucleolus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the heat shock protein 70 family.
SWISS:
P38646
Gene ID:
3313
Database links:
Entrez Gene: 3313 Human
Entrez Gene: 15526 Mouse
Entrez Gene: 291671 Rat
Omim: 600548 Human
SwissProt: P38646 Human
SwissProt: P38647 Mouse
SwissProt: P48721 Rat
Unigene: 184233 Human
Unigene: 209419 Mouse
Unigene: 7535 Rat
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