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肌动蛋白α/α-SMA/α Actin抗体10196
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品牌名称：$brandModel.Title型号：10196 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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中文名称肌动蛋白α/α-SMA/α Actin抗体
别 名alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha cardiac actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5
研究领域 肿瘤 细胞生物 免疫学 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, (predicted: Rat, Rabbit, )
产品应用 WB=1:5000-20000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µg/Test ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
细胞定位 细胞浆
性 状 Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human alpha-SMA:165-260/377
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
产品介绍 All eukaryotic cells express Actin, which often constitutes as much as 50% of total cellular protein. Actin filaments can ｆorm both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one Actin gene, higher eukaryotes have several isoｆorms encoded by a family of genes. At least six types of Actin are present in mammalian tissues and fall into three classes. alpha-Actin expression is limited to various types of muscle, whereas beta- and gamma-Actin are the principle constituents of filaments in other tissues. Members of the small GTPase family regulate the organization of the Actin cytoskeleton. Rho controls the assembly of Actin stress fibers and focal adhesion. Rac regulates Actin filament accumulation at the plasma membrane. Cdc42 stimulates ｆormation of filopodia.
Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subunit:
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the ｆorm of a two-stranded helix. Each actin can bind to 4 others.
Subcellular Location:
Cytoplasm, cytoskeleton.
Post-translational modifications:
Oxidation of Met-46 by MICALs (MICAL1, MICAL2 or MICAL3) to ｆorm methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced (By similarity).
DISEASE:
Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
Similarity:
Belongs to the actin family.
SWISS:
P62736
Gene ID:
59
Database links:
Entrez Gene: 101021287 Baboon
Entrez Gene: 515610 Cow
Entrez Gene: 59 Human
Entrez Gene: 11475 Mouse
Entrez Gene: 733615 Pig
Entrez Gene: 100009271 Rabbit
Entrez Gene: 81633 Rat
Omim: 102620 Human
SwissProt: P62739 Cow
SwissProt: P62736 Human
SwissProt: P62737 Mouse
SwissProt: P62740 Rabbit
SwissProt: P62738 Rat
Unigene: 500483 Human
Unigene: 213025 Mouse
Unigene: 195319 Rat
Unigene: 3114 Rat
热门标签：磷酸化叉头蛋白家族1（Ser319）抗体,雅吉抗体,一抗
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