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泛素蛋白连接酶抗体Ys-14265R
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品牌名称：$brandModel.Title型号：Ys-14265R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
产品编号Ys-14265R
英文名称Deltex
中文名称E3泛素蛋白连接酶抗体DTX1抗体
别 名Deltex homolog 1 (Drosophila); Deltex protein 1; Deltex-1; Deltex1; Dtx1; E3 ubiquitin protein ligase DTX1; FXI-T1; Fxit 1; Fxit1; DTX1_HUMAN; hDTX1; hDx 1; mDTX1; Protein deltex 1.
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, (predicted: Human, Rat, Pig, Cow, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量67kDa
细胞定位细胞核 细胞浆
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Deltex: 351-450/620
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix tranｓcription factor activity. [provided by RefSeq, Jul 2008]
Function:
Deltex is a RING finger ubiquitin ligase which is conserved from Drosophila to Humans and is a regulator of Notch signaling pathway. Deltex regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex is implicated in neurogenesis, lymphogenesis and myogenesis as well as marginal zone B cell differentiation.
Subunit:
Homodimer. May ｆorm a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH.
Subcellular Location:
Cytoplasm and Nucleus. Note: Predominantly cytoplasmic, partially nuclear.
Tissue Specificity:
Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
Post-translational modifications:
Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
Similarity:
Belongs to the Deltex family.
Contains 1 RING-type zinc finger.
Contains 2 WWE domains.
SWISS:
Q86Y01
Gene ID:
1840
热门标签：泛素蛋白连接酶抗体,雅吉抗体
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