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锚定蛋白G抗体YS-2415R
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品牌名称：$brandModel.Title型号：YS-2415R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
产品编号Ys-2415R
英文名称Ankyrin G
中文名称锚定蛋白G抗体
别 名ANK-3; ANK 3; ANK3; ANK3_HUMAN; ankyrin 3 (G); Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin 3, node of Ranvier; Ankyrin G119; Ankyrin-3; Ankyrin-G; brain specific ankyrin G; CHANK3.
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用ELISA=1:5000-10000 Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量481/220kDa
细胞定位细胞浆
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Ankyrin G: 1001-1200/4377
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍human: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoｆorms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple tranｓcript variants encoding several different isoｆorms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq]
mouse: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple tranｓcript variants encoding different isoｆorms.
Function:
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments.
Subunit:
Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity). Interacts (via N-terminal ANK repeats) with SCHIP1 isoｆorm 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG.
Subcellular Location:
Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). Lysosome (By similarity). Note=In skeletal muscle, localized at costameres and neuromuscular junctions (By similarity). In macrophages, associated with lysosomes (By similarity).
Tissue Specificity:
Expressed in brain, neurons and other tissues.
DISEASE:
Note=Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility.
Similarity:
Contains 23 ANK repeats.
Contains 1 death domain.
Contains 2 ZU5 domains.
SWISS:
Q12955
热门标签：锚定蛋白G抗体,雅吉抗体
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