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磷酸化周期素B1抗体Ys-3122R
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品牌名称：$brandModel.Title型号：Ys-3122R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
产品编号Ys-3122R
英文名称Phospho-Cyclin B1 (Ser147)
中文名称磷酸化周期素B1抗体
别 名Cyclin B1 (phospho S147); Cyclin B1 (phospho-Ser147); p-Cyclin B1 (S147); p-Cyclin B1 (Ser147); p-Cyclin B1 (phospho S147); CCNB 1; CCNB; CCNB1; CCNB1_HUMAN; G2 mitotic specific cyclin B1; G2/mitotic-specific cyclin-B1.
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1µg /Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量48kDa
细胞定位细胞核 细胞浆
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human Cyclin B1 around the phosphorylation site of Ser147: AF(p-S)DV
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to ｆorm the maturation-promoting factor (MPF). Two alternative tranｓcripts have been found, a constitutively expressed tranｓcript and a cell cycle-regulated tranｓcript, that is expressed predominantly during G2/M phase. The different tranｓcripts result from the use of alternate tranｓcription initiation sites. [provided by RefSeq, Jul 2008].
Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Subunit:
Interacts with the CDC2 protein kinase to ｆorm a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to ｆorm an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization.
Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.
Post-translational modifications:
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site
Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.
SWISS:
P14635
Gene ID:
891
热门标签：磷酸化周期素B1抗体,雅吉抗体
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