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平滑肌肌球蛋白重链抗体Ys-1956R
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品牌名称：$brandModel.Title型号：Ys-1956R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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产品编号Ys-1956R
英文名称smooth muscle Myosin heavy chain 11
中文名称平滑肌肌球蛋白重链抗体
别 名SMMHC; Myosin 11; Myosin-11; Myosin, smooth muscle, heavy chain; Myosin Smooth Muscle; AAT 4; AAT4; DKFZp686D10126; DKFZp686D19237; FAA 4; FAA4; FLJ35232; KIAA0866; MGC126726; MGC32963; MYH 11; MYH11 protein; Myosin heavy chain 11 smooth muscle; Myosin heavy chain smooth muscle isoｆorm; Myosin heavy polypeptide 11 smooth muscle; Myosin11; SMHC; Smooth muscle myosin heavy chain isoｆorm SM1; MYH11_HUMAN.
抗体来源Rabbit
克隆类型Polyclonal
交叉反应(predicted: Human, Mouse, Rat, Dog, Cow, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量227kDa
细胞定位细胞浆 细胞膜
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SMHC: 1801-1979/1979
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16[inv(16)(p13q22)] produces a chimeric tranｓcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoｆorms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced tranｓcript variants encoding different isoｆorms have been identified.
MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP.
Function:
Muscle contraction.
Subunit:
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Subcellular Location:
Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils.
Tissue Specificity:
Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea.
DISEASE:
Note=A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
Familial aortic aneurysm thoracic 4 (AAT4) [MIM:132900]: A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Contains 1 IQ domain. Contains 1 myosin head-like domain.
SWISS:
P35749
Gene ID:
4629
热门标签：平滑肌肌球蛋白重链抗体,雅吉抗体
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