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细胞毒性受体NK-p30抗体Ys-2418R
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品牌名称：$brandModel.Title型号：Ys-2418R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
产品编号Ys-2418R
英文名称NCR3
中文名称细胞毒性受体NK-p30抗体
别 名Natural cytotoxicity triggering receptor 3; 1C7; Activating natural killer receptor p30; Activating NK A1 receptor; CD337; CD337 antigen; LY117; Lymphocyte antigen 117; MALS; Natural cytotoxicity triggering receptor 3; Natural cytotoxicity triggering receptor 3; Natural killer cell p30 related protein; Natural killer cell p30 related protein; Natural killer cell p30-related protein; NK-p30; NKp30; NCTR3_HUMAN.
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, (predicted: Rat, Dog, Horse, Rabbit, )
产品应用ELISA=1:5000-10000 Flow-Cyt=2ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量20kDa
细胞定位细胞膜
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD337: 81-180/201
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍NCR3 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. It is a member of the Ig superfamily and may cooperate with NKp46 and NKp44 in the induction of cytotoxicity against a variety of target cells and is selectively expressed by all NK cells, both freshly isolated and cultured in IL2, thus representing an optimal marker for NK cell identification. Similar to NKp46 and CD16, NKp30 associated with CD3 zeta chains becomes tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type and by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion. It is selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
Function:
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
Subunit:
Homodimer in the unliganted ｆorm. Interacts with CD3Z. Interacts with and is activated by binding to B7H6. Interacts with and is activated by binding to BAG6.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 1 Ig-like (immunoglobulin-like) domain.
SWISS:
O14931
Gene ID:
259197
热门标签：细胞毒性受体NK-p30抗体,雅吉抗体
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