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磷酸化心脏肌球蛋白轻链2抗体Ys-3295R
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品牌名称：$brandModel.Title型号：Ys-3295R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
产品编号Ys-3295R
英文名称Phospho-MYL (Ser19)
中文名称磷酸化心脏肌球蛋白轻链2抗体
别 名Cardiac myosin light chain-2; Cardiac ventricular myosin light chain 2; CMH10; MLC 2v; MLC2; MYL 2; Myosin light chain 2 regulatory cardiac slow; Myosin light polypeptide 2 regulatory cardiac slow; Myosin regulatory light chain 2 ventricular cardiac muscle isoｆorm; Myosin regulatory light chain 2; ventricular/cardiac muscle isoｆorm; Regulatory light chain of myosin; RLC of myosin; Slow cardiac myosin regulatory light chain 2; MLRV_HUMAN.
产品类型磷酸化抗体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量18kDa
细胞定位细胞浆
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human MYL2 around the phosphorylation site of Ser19: VF(p-S)MF
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Subunit:
Myosin is a hexamer of 2 heavy chains and 4 light chains.
Subcellular Location:
Cytoplasm, myofibril, sarcomere, A band
Post-translational modifications:
N-terminus is methylated by METTL11A/NTM1.
Phosphorylated by MYLK3.
DISEASE:
Defects in MYL2 are the cause of familial hypertrophic cardiomyopathy type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant ｆorms with high risk of cardiac failure and sudden cardiac death.
Similarity:
Contains 3 EF-hand domains.
热门标签：磷酸化心脏肌球蛋白轻链2抗体,抗体
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