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信号淋巴细胞活化分子CD150抗体Ys-2709R
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产品编号Ys-2709R
英文名称CD150/SLAM
中文名称信号淋巴细胞活化分子CD150抗体
别 名CD150 antigen; Cdw150; SLAM / CD150; Estm51; Ipo 3; Ipo3; MGC151472; MGC151476; Signaling lymphocytic activation molecule; Signaling lymphocytic activation molecule family member 1; Signaling lymphocytic activation molecule precursor; Slaf1; SLAM family, member 1; Slamf; Slamf1; SLAMF1 protein.
研究领域免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量70kDa
细胞定位细胞膜
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD150: 231-335/335
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍SLAM, a novel glycoprotein of 37kDa, designated SLAM (Signaling Lymphocyte Activation Molecule) or CDw150, belongs to the immunoglobulin gene superfamily and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound ｆorm of SLAM and the soluble and cytoplasmic isoｆorms of SLAM, and the expression levels of membrane bound SLAM on B cells are rapidly regulated after activation in vitro. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells.
Function:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Subunit:
nteracts (via cytoplasmic domain) with SH2D1A, and withPTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus Hprotein and acts as a receptor for this virus.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.
Tissue Specificity:
Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.
Post-translational modifications:
Phosphorylated by FYN.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
Q13291
热门标签：信号淋巴细胞活化分子CD150抗体,抗体
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