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β2-微球蛋白抗体/β2微球蛋白抗体Ys-6294R
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品牌名称：$brandModel.Title型号：Ys-6294R 原产地：中国大陆 更新时间：2026/11/10 8:31:36
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详细内容
产品编号Ys-6294R
英文名称beta 2 Microglobulin
中文名称β2-微球蛋白抗体
别 名B2M; Beta 2 microglobulin precursor; Beta-2 Microglobulin; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta 2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin ｆorm pI 5.3; CDABP0092. β2 Microglobulin; β2-Microglobulin; β-2-Microglobulin;
研究领域肿瘤 心血管 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, (predicted: Rat, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量12kDa
细胞定位分泌型蛋白
性 状Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human beta 2 Microglobulin: 51-119/119
亚 型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can ｆorm amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].
Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Subunit:
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.
Subcellular Location:
Secreted. Detected in serum and urine.
Post-translational modifications:
Glycation of Ile-21 is observed in long-term hemodialysis patients.
DISEASE:
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Similarity:
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain
热门标签：β2-微球蛋白抗体/β2微球蛋白抗体,抗体
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