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Small Cardioactive Peptide B (SCPB)

MCE 国际站：Small Cardioactive Peptide B (SCPB)

品牌：MedChemExpress (MCE)

货号：HY-P1495

CAS 号：84746-43-0

生物活性：小心脏活性肽 B (SCPB) 是一种神经活性肽，可刺激心脏和鳃组织颗粒组分中的腺苷酸环化酶活性，其 EC50 分别为 0.1 和 1.0 µM。

体外研究(In Vitro)：Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0µM, respectively[1]. MCE尚未独立确认这些方法的准确性。 仅供参考。

分子量：1141.41

Formula：C52H80N14O11S2

性状：固体

颜色：White to off-white

Sequence：Met-Asn-Tyr-Leu-Ala-Phe-Pro-Arg-Met-NH2

Sequence Shortening：MNYLAFPRM-NH2

运输条件：美国大陆地区的室温；其他地区可能有所不同。

储存方式：密封储存，避光防潮，氮气保护。粉末 -80°C 保存 2 年

提供质量检测报告：Data Sheet、SDS、COA、LCMS、元素分析报告、产品使用指南

产品活性：Small Cardioactive Peptide B (SCPB) 是一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC50 分别为 0.1 和 1.0 µM。

IC50 & Target：EC50: 0.1 µM (adenylate cyclase, in heart tissues), 1.0 µM (adenylate cyclase, in gill tissues)[1]

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热门产品线：抑制剂 | 稳定性同位素标记物 | 脂质 | 糖类

Trending products：Inhibitors | Isotope-Labeled Compounds | Lipids | Saccharides

参考文献：
[1]. Cawthorpe DR, et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24.